What is the LKM-1 Antibody Test?
A blood test that detects LKM-1 antibodies, which target liver and kidney cells. These antibodies are primarily associated with Autoimmune Hepatitis Type 2 (AIH-2).
🩸 Purpose of the Test
Diagnosing Autoimmune Hepatitis Type 2
Differentiating AIH-2 from other liver diseases, such as viral hepatitis
Monitoring disease progression & treatment response
📊 Normal Ranges
Negative: No LKM-1 antibodies detected
Positive: Presence of LKM-1 antibodies (suggests AIH-2 or other conditions)
(Note: Values can vary by laboratory standards)
⚠️ Conditions Associated with LKM-1 Antibodies
Autoimmune Hepatitis Type 2 (Most Common)
Chronic Hepatitis C (rare cases)
Drug-induced liver injury (rare)
📝 Additional Testing May Include:
Liver Function Tests (LFTs)
Other Autoimmune Markers (e.g., ANA, SMA)
Liver Biopsy (for confirmation)
👩‍⚕️ When Should You Get Tested?
Persistent elevated liver enzymes (ALT, AST)
Symptoms: Fatigue, jaundice, abdominal pain
Family history of autoimmune liver disease