🔍 What is the LE Cells Test?
The LE (Lupus Erythematosus) Cells Test is a microscopic examination of white blood cells to detect LE cells—a type of abnormal immune cell associated with systemic lupus erythematosus (SLE) and other autoimmune diseases. This test was historically used for lupus diagnosis but has largely been replaced by more advanced tests like ANA (Antinuclear Antibody) and Anti-dsDNA tests.
🎯 Purpose of the Test
Detect LE cells in suspected lupus cases
Support the diagnosis of systemic lupus erythematosus (SLE)
Differentiate lupus from other autoimmune disorders
Assist in evaluating disease progression
📊 Normal Ranges & Interpretation
Result
Interpretation
Possible Condition
Negative
No LE cells detected (Normal)
No active lupus or related disease
Positive
LE cells present (Abnormal)
Suggests Lupus Erythematosus (SLE) or another autoimmune disorder
🔹 Note: A positive result alone is not conclusive for lupus; further testing is required.
⚠️ Conditions Associated with Positive LE Cells Test
Systemic Lupus Erythematosus (SLE)
Drug-Induced Lupus
Other Autoimmune Diseases (e.g., Rheumatoid Arthritis, Scleroderma)
Chronic Inflammatory Conditions
📝 Additional Testing May Include:
ANA (Antinuclear Antibody) Test (More specific for lupus diagnosis)
Anti-dsDNA & Anti-Smith Antibody Tests (Lupus confirmation)
Erythrocyte Sedimentation Rate (ESR) & C-Reactive Protein (CRP) (Inflammation markers)
Complete Blood Count (CBC) & Kidney Function Tests (To assess lupus-related complications)
👩‍⚕️ When Should You Get Tested?
Symptoms of lupus, such as fatigue, joint pain, skin rashes, and fever
Unexplained chronic inflammation
Autoimmune disease screening in high-risk individuals
Monitoring lupus progression or treatment response