🔍 What is the CD45 Test?
The CD45 test detects Leukocyte Common Antigen (LCA), a protein found on the surface of white blood cells (leukocytes). It helps in the diagnosis of leukemia, lymphoma, and immune disorders.
🎯 Purpose of the Test
Identify leukocyte (white blood cell) populations
Differentiate types of blood cancers (Leukemia, Lymphoma, etc.)
Diagnose immune system disorders
Assist in bone marrow and lymph node evaluations
📊 Normal Ranges (Varies Based on Cell Type & Testing Method)
✅ CD45+ Cells: Present in most white blood cells
🚫 CD45- Cells: Absence may indicate abnormal or cancerous cells
🔬 Expression Levels:
High CD45 Expression: Found in mature lymphocytes
Low or Absent CD45 Expression: Seen in some leukemias or lymphomas
⚠️ Conditions Associated with Abnormal CD45 Levels
Acute & Chronic Leukemia
Lymphoma (Hodgkin’s & Non-Hodgkin’s)
Bone Marrow Disorders
Immune System Diseases (e.g., Severe Combined Immunodeficiency - SCID)
📝 Additional Testing May Include:
Flow Cytometry (to classify white blood cells)
Complete Blood Count (CBC)
Bone Marrow Biopsy
👩‍⚕️ When Should You Get Tested?
Unexplained Fatigue or Frequent Infections
Swollen Lymph Nodes or Enlarged Spleen
Abnormal Blood Test Results (Suspicious White Blood Cell Count)
Ongoing Monitoring for Blood Cancer Patients