🔍 What is the LAP Score Test?
The Leukocyte Alkaline Phosphatase (LAP) Score Test measures the activity of alkaline phosphatase enzyme in white blood cells (neutrophils). It helps differentiate between various blood disorders, including leukemia and infections.
🎯 Purpose of the Test
Diagnose and distinguish Chronic Myeloid Leukemia (CML) from Leukemoid Reactions
Assess bone marrow and white blood cell function
Evaluate infections, inflammatory conditions, or myeloproliferative disorders
📊 Normal Ranges (May vary by lab & individual health conditions)
✅ Normal LAP Score: 20 – 100
🔺 High LAP Score (>100):
Infections (bacterial, tuberculosis, sepsis)
Inflammatory disorders (rheumatoid arthritis, pregnancy, polycythemia vera)
🔻 Low LAP Score (<20):
Chronic Myeloid Leukemia (CML)
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Aplastic Anemia
⚠️ Conditions Associated with Abnormal LAP Scores
High LAP: Infection, pregnancy, polycythemia vera
Low LAP: Chronic Myeloid Leukemia (CML), bone marrow failure
📝 Additional Testing May Include:
Complete Blood Count (CBC)
Bone Marrow Biopsy
Philadelphia Chromosome Testing (for CML diagnosis)
👩‍⚕️ When Should You Get Tested?
Unexplained high or low white blood cell counts
Suspicion of leukemia or blood disorders
Chronic infections or unexplained inflammation