📌 What is the Intrinsic Factor IgG Antibody Test?
A blood test that detects Intrinsic Factor (IF) IgG antibodies, which attack intrinsic factor, a protein needed for vitamin B12 absorption.
Used to diagnose pernicious anemia, an autoimmune condition that leads to B12 deficiency.
🎯 Purpose of the Test
✅ Diagnoses pernicious anemia (a major cause of vitamin B12 deficiency).
✅ Helps differentiate pernicious anemia from other types of anemia.
✅ Evaluates unexplained B12 deficiency and neurological symptoms.
📊 Normal Ranges & Interpretation
🔹 Normal Result: No detectable intrinsic factor antibodies (Negative result).
🔹 Abnormal Result: Detectable intrinsic factor antibodies (Positive result), indicating pernicious anemia or an autoimmune reaction affecting B12 absorption.
📝 Test Procedure
1️⃣ A blood sample is drawn.
2️⃣ The sample is analyzed using ELISA (enzyme-linked immunosorbent assay) or chemiluminescence immunoassay.
3️⃣ Results determine the presence of intrinsic factor IgG antibodies.
⚠️ Who Should Get Tested?
🔹 Individuals with symptoms of B12 deficiency, including:
Fatigue, weakness, pale skin
Tingling or numbness in hands/feet
Memory issues, difficulty concentrating
🔹 People with macrocytic anemia (large red blood cells).
🔹 Individuals with autoimmune disorders (e.g., thyroid disease, type 1 diabetes).
✅ Why is This Test Important?
✔️ Early detection of pernicious anemia prevents complications like nerve damage.
✔️ Helps in the proper treatment of B12 deficiency.
✔️ Differentiates autoimmune causes of anemia from other conditions.