📌 What is the IL28B RS12979860 Genotyping Test?
A genetic test that analyzes the rs12979860 single nucleotide polymorphism (SNP) in the IL28B gene.
The IL28B gene plays a key role in the body's immune response to viral infections, especially Hepatitis C Virus (HCV).
Helps predict a patient’s response to interferon-based treatment for Hepatitis C.
🎯 Purpose of the Test
✅ Identifies genetic variations that influence HCV treatment success.
✅ Helps in personalizing treatment plans for Hepatitis C patients.
✅ Assesses the likelihood of spontaneous HCV clearance without treatment.
✅ Provides insights into immune response differences in infectious diseases.
📊 Normal Ranges & Interpretation
🔹 CC Genotype (Favorable Response) – Higher likelihood of successful response to interferon-based HCV therapy and potential spontaneous viral clearance.
🔹 CT or TT Genotype (Less Favorable Response) – Lower chance of responding to interferon-based treatment and higher risk of chronic Hepatitis C infection.
(There is no “normal” or “abnormal” result; interpretation is based on genotype.)
📝 Test Procedure
1️⃣ A blood sample or buccal (cheek) swab is collected.
2️⃣ DNA is extracted and analyzed using PCR (Polymerase Chain Reaction) technology.
3️⃣ Results determine whether the patient has the CC, CT, or TT genotype.
⚠️ Who Should Get Tested?
🔹 Hepatitis C patients, especially those considering interferon-based therapy.
🔹 Individuals with a history of poor response to antiviral treatment.
🔹 Patients with chronic HCV infections, especially HCV genotype 1.
🔹 Those at risk of long-term liver complications due to viral infections.
✅ Why is This Test Important?
✔️ Helps determine the best treatment strategy for Hepatitis C.
✔️ Predicts treatment success or failure, avoiding ineffective therapies.
✔️ Assists in personalized medicine approaches for infectious diseases.