🧪 What is the AMA Test?
The Anti-Mitochondrial Antibody (AMA) test detects autoantibodies that attack mitochondria, the energy-producing structures in cells. It is primarily used to diagnose Primary Biliary Cholangitis (PBC), a chronic liver disease.
📊 Normal Ranges:
✅ Negative: <1:40 (No AMA detected)
⚠️ Borderline: 1:40 - 1:80 (Weakly positive, further testing needed)
❌ Positive: >1:80 (Suggests possible PBC or other autoimmune liver disease)
🎯 Purpose of the AMA Test:
✔️ Diagnose Primary Biliary Cholangitis (PBC)
✔️ Differentiate PBC from other liver diseases
✔️ Monitor disease progression & response to treatment
✔️ Identify autoimmune conditions affecting the liver
🏥 Who Might Need This Test?
👩‍⚕️ Individuals with symptoms of PBC, such as:
Chronic fatigue
Itchy skin (pruritus)
Jaundice (yellowing of skin & eyes)
Abdominal pain
Unexplained elevated liver enzymes
📌 Important Notes:
90–95% of people with PBC test positive for AMA
A positive AMA test alone does not confirm PBC—liver function tests & biopsy may be required
The test is performed using Indirect Immunofluorescence Assay (IFA)
🔬 Next Steps:
📍 If AMA is positive, follow-up tests (e.g., liver function tests, biopsy) may be recommended.
📍 If AMA is negative but symptoms persist, further testing for liver disorders is advised.