What is an AMA Test?
The Anti-Mitochondrial Antibody (AMA) test detects autoantibodies that target mitochondria. These antibodies are primarily associated with primary biliary cholangitis (PBC), a chronic liver disease.
Normal Range:
Negative / Undetectable: Titer <1:40
Positive: Titer ≥1:40 (May indicate PBC or other conditions)
(Ranges may vary by laboratory methods)
Purpose of the Test:
✅ Diagnose Primary Biliary Cholangitis (PBC) – Over 90% of people with PBC test positive for AMA.
✅ Monitor Liver Disease Progression – Helps assess the severity of liver damage.
✅ Differentiate Liver Conditions – Used to distinguish PBC from other liver diseases.
✅ Evaluate Symptoms – Ordered if experiencing fatigue, jaundice, itching, or abdominal pain.
What Can Affect AMA Test Results?
🔹 Positive AMA without PBC: May be seen in autoimmune hepatitis, chronic liver disease, or infections.
🔹 Negative AMA but PBC Symptoms: Some cases of PBC can occur without detectable AMA.
How is the Test Performed?
A blood sample is drawn from a vein and analyzed for AMA presence using immunological methods.
📌 When to Get Tested? If you have unexplained liver dysfunction or symptoms suggestive of PBC.