What is the Anti-DNase B Test?
The Anti-DNase B (ADB) test detects antibodies against DNase B, an enzyme produced by Group A Streptococcus bacteria. This test helps diagnose a past streptococcal infection, which can lead to complications like rheumatic fever and post-streptococcal glomerulonephritis.
Normal Range:
Adults & Children: < 85 - 200 U/mL (Varies by age and laboratory)
Elevated Levels: > 240 U/mL (May indicate a recent streptococcal infection)
(Reference values may vary depending on laboratory methods)
Purpose of the Test:
✅ Detect Recent Streptococcal Infections – Identifies past Group A Streptococcus infections, even if no symptoms were present.
✅ Diagnose Post-Streptococcal Complications – Helps confirm conditions like rheumatic fever or post-streptococcal glomerulonephritis.
✅ Monitor Autoimmune Reactions – Used when strep throat or scarlet fever complications are suspected.
✅ Differentiate Bacterial vs. Other Infections – Helps rule out other causes of inflammation or fever.
What Can Affect Anti-DNase B Test Results?
🔹 Elevated Anti-DNase B: Suggests a recent streptococcal infection, even if throat cultures are negative.
🔹 Persistently High Levels: May indicate ongoing immune system response.
🔹 False-Negative Results: Not all streptococcal infections trigger a rise in Anti-DNase B antibodies.
How is the Test Performed?
A blood sample is drawn and analyzed using immunological methods to measure antibody levels.
📌 When to Get Tested? If experiencing joint pain, fever, swelling, kidney issues, or suspected post-streptococcal complications.