What is the Anti-Cardiolipin Antibody IgM Test?
The Anti-Cardiolipin Antibody (ACA) IgM test detects IgM autoantibodies against cardiolipin, a phospholipid found in cell membranes. These antibodies are associated with antiphospholipid syndrome (APS), an autoimmune disorder linked to blood clotting issues and pregnancy complications.
Normal Range:
Negative: < 12 MPL units (No significant antibodies detected)
Borderline: 12 - 20 MPL units (May require monitoring)
Positive: > 20 MPL units (Indicates increased risk of clotting disorders)
(Reference values may vary depending on laboratory methods)
Purpose of the Test:
✅ Diagnose Antiphospholipid Syndrome (APS) – Helps identify autoimmune clotting disorders.
✅ Assess Risk of Blood Clots (Thrombosis) – High levels are linked to deep vein thrombosis (DVT), stroke, or pulmonary embolism.
✅ Investigate Recurrent Miscarriages – Helps determine if APS is causing pregnancy complications.
✅ Support Lupus Diagnosis – Often tested alongside lupus anticoagulant and anti-beta-2 glycoprotein I antibodies.
What Can Affect Anti-Cardiolipin Antibody IgM Test Results?
🔹 Positive IgM Antibodies: May indicate APS, lupus, infections, or temporary immune responses.
🔹 Negative but Symptoms Present: Other APS-related antibodies may be tested.
🔹 Transient Positives: Infections or certain medications can cause temporary elevations.
How is the Test Performed?
A blood sample is drawn and analyzed using ELISA (Enzyme-Linked Immunosorbent Assay) or similar immunological methods.
📌 When to Get Tested? If experiencing unexplained blood clots, recurrent miscarriages, stroke, or autoimmune disease symptoms.