What is the Anti-Cardiolipin Antibody IgG Test?
The Anti-Cardiolipin Antibody (ACA) IgG test detects IgG autoantibodies against cardiolipin, a phospholipid involved in blood clotting. High levels of these antibodies are linked to antiphospholipid syndrome (APS), a disorder that increases the risk of blood clots, strokes, and pregnancy complications.
Normal Range:
Negative: < 15 GPL units (No significant antibodies detected)
Borderline: 15 - 20 GPL units (May require monitoring)
Positive: > 20 GPL units (Indicates increased risk of clotting disorders)
(Reference values may vary depending on laboratory methods)
Purpose of the Test:
✅ Diagnose Antiphospholipid Syndrome (APS) – Helps detect an autoimmune disorder that causes excessive blood clotting.
✅ Assess Risk of Blood Clots (Thrombosis) – Elevated IgG levels increase the risk of deep vein thrombosis (DVT), stroke, or pulmonary embolism.
✅ Investigate Recurrent Miscarriages – Identifies APS-related pregnancy complications.
✅ Monitor Autoimmune Diseases – Often tested alongside lupus anticoagulant and anti-beta-2 glycoprotein I antibodies to assess systemic lupus erythematosus (SLE).
What Can Affect Anti-Cardiolipin Antibody IgG Test Results?
🔹 High IgG Antibodies: Strongly associated with persistent APS and increased clotting risk.
🔹 Temporary Positives: Some infections or medications may cause short-term antibody elevation.
🔹 Negative but Symptoms Present: Additional APS-related antibody tests may be required.
How is the Test Performed?
A blood sample is drawn and analyzed using ELISA (Enzyme-Linked Immunosorbent Assay) or similar immunological methods.
📌 When to Get Tested? If experiencing unexplained blood clots, recurrent miscarriages, stroke, or autoimmune disease symptoms.