📌 What is the AAT Test?
A blood test that measures the amount of alpha-1 antitrypsin (AAT), a protein produced by the liver that protects the lungs from damage. Low levels may indicate genetic AAT deficiency, which increases the risk of lung and liver disease.
📊 Normal Ranges
✔ Adults: 100 - 200 mg/dL (varies by lab)
🚨 Low AAT Levels May Indicate:
🔻 Alpha-1 antitrypsin deficiency (AATD) – a genetic disorder
🔻 Early-onset emphysema or chronic obstructive pulmonary disease (COPD)
🔻 Liver disease (cirrhosis, hepatitis, neonatal jaundice)
🚨 High AAT Levels May Indicate:
🔺 Inflammation or infection
🔺 Chronic diseases (e.g., rheumatoid arthritis, cancer)
🎯 Purpose of the Test
✅ Diagnoses AAT deficiency, which can lead to lung and liver disease
✅ Helps determine risk for emphysema and COPD
✅ Assesses liver disease in newborns and adults
✅ Evaluates unexplained lung or liver symptoms
💡 Key Facts
🔹 AAT deficiency is inherited and can be confirmed with genetic testing
🔹 Smoking worsens lung damage in AAT-deficient individuals
🔹 Replacement therapy (AAT infusions) may help slow lung disease progression
🔹 Liver transplantation may be needed in severe cases of AATD-related liver disease